Neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis (ALS), are characterized by the progressive loss of structure or function of neurons in the brain and spinal cord. While genetic and environmental factors are primary contributors, chronic stress is increasingly recognized as a significant risk factor. Stress triggers the release of glucocorticoids, like cortisol, which, when elevated for extended periods, can lead to neuronal damage, inflammation, and impaired neurogenesis in regions like the hippocampus. These effects exacerbate the pathology of neurodegenerative diseases, accelerating cognitive and motor decline. Addressing stress through lifestyle modifications, therapeutic interventions, and stress-reduction techniques is an emerging area of interest for both prevention and management of these debilitating conditions.
